乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Names and Identifiers

Name	ethyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate
Synonyms	Apixaban-2 Apixaban Impurity B 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazono)acetate ethyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate (Z)-ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate(Apixaban) acetic acid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethyl ester Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide
CAS	27143-07-3
EINECS	608-053-7
InChI	InChI=1/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Physico-chemical Properties

Molecular Formula	C11H13ClN2O3
Molar Mass	256.69
Density	1.23
Melting Point	94℃
Boling Point	349.0±44.0 °C(Predicted)
Flash Point	164.842°C
Solubility	Chloroform (Sparingly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Yellow to Dark Yellow
pKa	11.63±0.10(Predicted)
Storage Condition	2-8°C
Sensitive	Irritant
Refractive Index	1.533
MDL	MFCD00446053
Use	This product is for scientific research only and shall not be used for other purposes.

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Reference Information

Introduction

[(4-methoxyphenyl) hydrazinyl] ethyl chloroacetate is an ester derivative, which is an intermediate in the synthesis of apixaban. Apixaban is a new type of oral factor Xa inhibitor jointly developed by Bristol-Myers Squibb and Pfizer. The trade name is Erroto. It is a new type of oral anticoagulant. By inhibiting an important coagulation factor Xa, apixaban can prevent thrombin production and thrombosis. Apixaban was developed by Bristal-Myers squibb Company. It has good bioavailability and high selectivity. It was listed in China in 2013. Apixaban is safe, the possibility of drug interaction is small, and there are many ways to eliminate it, which is expected to be used in special groups suffering from liver disease or kidney function damage.

Use

[(4-methoxyphenyl) hydrazinyl] ethyl chloroacetate is a useful research chemical.
apixaban intermediate

Last Update：2024-04-18 10:26:07

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乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯

ethyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate

CAS: 27143-07-3

Molecular Formula: C11H13ClN2O3

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Names and Identifiers

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Physico-chemical Properties

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Reference Information

Supplier List

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 Request for Quotation

ethyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate

CAS: 27143-07-3

Molecular Formula: C11H13ClN2O3

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Names and Identifiers

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Physico-chemical Properties

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯 - Reference Information

Supplier List

乙酸,2-氯-2-[2-(4-甲氧基苯基)亚肼基],乙酯